Distribution of Nogo in the heart and its role in cardiovascular disease

Author: Su-Xin ZHANG ¹ ; Yao-Wen HU ¹ ; Lin-Hua QIN ¹ ; Yan-Rong SUN ² ; Wen-Juan WANG ² ; Su-Xin ZHANG ³ ; Yan-Rong SUN ³ ; Wen-Juan WANG ³ ; Hao-Zhe SUN ³ ; Yao-Wen HU ³ ; Lin-Hua QIN ³
Author Information

1. Clinic Class 4, School of Basic Medical Sciences
2. Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences
3. Clinic Eight Year Program, Peking University Health Science Center
Publication Type:Journal Article
Keywords: Coronary vascular regulation; Heart failure; Myocardial apoptosis; Myocardial fibrosis; Myocardial infarction; Nogo
From: Acta Anatomica Sinica 2021;52(3):495-498
CountryChina
Language:Chinese
Abstract: As a member of the reticulin family, Nogo is mainly involved in processes such as tissue regeneration, apoptosis and tumor growth after tissue injury. Cardiovascular disease is one of the main diseases that threaten human health at present. In recent years, research on Nogo in the cardiovascular system has become increasingly extensive. Changes in the expression of Nogo during myocardial fibrosis, myocardial cell apoptosis and vascular remodeling suggest that it may play a certain role. This article reviews the distribution of Nogo in the heart and its role in cardiovascular disease, in order to reveal its possible role and mechanism in cardiovascular diseases.