Molecular mechanism underlying vascular development in the brain
10.16098/j.issn.0529-1356.2022.05.022
- Author:
Si-Qi ZHANG
1
;
Chen-Xi KANG
1
;
Pei-Yan ZHANG
1
;
Hai-Xia LUO
1
;
Fei LI
2
;
Juan SHI
2
;
Yun-Qing LI
2
Author Information
1. School of Basic Medicine, Air Force Military Medical University, Six Student Brigade
2. Histology and Embryology and K.K. Leung Brain Research Centre, Department of Anatomy
- Publication Type:Journal Article
- Keywords:
Angiogenesis;
Cerebral angiogenesis;
Notch signaling pathway;
Vascular endothelial growth factor;
Wnt signaling pathway
- From:
Acta Anatomica Sinica
2022;53(5):680-686
- CountryChina
- Language:Chinese
-
Abstract:
As the pipelines of nutrient and oxygen in the brain, cerebral vessels play an important role in the development and normal function of the brain. The development of the cerebrovascular system is divided into two processes, primitive vasculogenesis and angiogenesis. In this review, we summarize the roles, regulation mechanisms, as well as the interactions of the essential signaling molecules, such as the family members of vascular endothelial growth factor（VEGF）, neuropillin, Wnt, Notch, Hedgehog, in the vessel development, aiming to provide a reference for the basic and clinical investigation and the prevention and treatment of vascular diseases. Reset.
