Distribution of mesencephalic astrocyte derived neurotrophic factor in human, mouse and rat brain
10.16098/j.issn.0529-1356.2022.05.002
- Author:
Xiao-Lu TANG
1
;
Pei WANG
1
;
Yan-Yan SU
1
;
Xue-Yan WU
1
;
Cong-Cong DENG
2
;
Ming-Hui CHEN
3
;
Kai TIAN
4
;
Hui MA
5
;
Yu-Xian SHEN
6
;
Yu-Xian SHEN
7
Author Information
1. Department of Human Anatomy, School of Basic Medical Sciences, Anhui Medical University
2. Grade of 2017, Majoring in Clinical Medicine, The Second Clinical Medical College, Anhui Medical University
3. Grade of 2017, Majoring in Clinical Medicine, The First Clinical Medical College, Anhui Medical University
4. Grade of 2018, Majoring in Clinical Medicine, The Second Clinical Medical College of Anhui Medical University
5. Grade of 2016, Majoring in Clinical Medicine, The First Clinical Medical College, Anhui Medical University
6. Biopharmaceutical Research Institute, Anhui Medical University
7. School of Basic Medical Sciences, Anhui Medical University
- Publication Type:Journal Article
- From:
Acta Anatomica Sinica
2022;53(5):551-556
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the distribution of mesencephalic astrocyte derived neurotrophic factor (MANF) within the brain in human, mice and rats and the comparison across the species. Methods An immunohistochemical method was applied to investigate the expression of MANF and to compare the differences among species in the brain of human specimens ( n = 5) , mice ( n = 6) , and rats ( n = 6). Results The expression of MANF varied in different brain regions in human, mice and rats. In human, in the cortex, the expression of MANF was the highest among all brain regions. In the subcortical areas or the nucleus, brainstem and cerebellum expression level of MANF were relatively lower. The distribution of MANF in mouse and rat brain were slightly different from that in human brain, but generally consistent. Conclusion The distribution pattern of MANF is similar across the species, however, within a species, MANF expression levels varies in different brain regions.
