Research progress on the relationship between Nogo protein and myocardial fibrosis
10.16098/j.issn.0529-1356.2022.05.021
- Author:
Yao-Wen HU
1
;
Yan-Rong SUN
1
;
Hao-Zhe SUN
1
;
Wen-Juan WANG
1
;
Su-Xin ZHANG
1
;
Li-Hua QIN
1
Author Information
1. Department of Anatomy and Histo Embryology, Peking University Health Science Center, School of Basic Medical Sciences
- Publication Type:Journal Article
- Keywords:
Myocardial fibrosis;
Nogo-A;
Nogo-B;
Nogo-C
- From:
Acta Anatomica Sinica
2022;53(5):674-679
- CountryChina
- Language:Chinese
-
Abstract:
Nogo protein is the fourth member of reticulin famity. Nogo mRNA produced by encoding gene transcription, forms three different RNA transcripts due to different promoter and splicing modes, namely Nogo-A, Nogo-B and Nogo-C protein. Nogo protein was first found in the central nervous system, and then proved to be widely expressed in peripheral tissues such as heart, liver and vascular endothelium. Studies have shown that Nogo protein can participate in the regulation of myocardial fibrosis through RhoA/Rho-associated kinase(ROCK) pathway, endoplasmic reticulum stress, Sce61 a and other signaling pathways. In this paper, the relationship between Nogo-A, Nogo-B, Nogo-C and myocardial fibrosis is briefly introduced.
