XRCC1 Polymorphisms and Risk of Papillary Thyroid Carcinoma in a Korean Sample.
10.3346/jkms.2011.26.8.991
- Author:
Ri A RYU
1
;
Kyung TAE
;
Hyun Jung MIN
;
Jin Hyeok JEONG
;
Seok Hyun CHO
;
Seung Hwan LEE
;
You Hern AHN
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, Hanyang University School of Medicine, Seoul, Korea. kytae@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Polymorphisms;
XRCC1;
SNP;
Papillary Thyroid Carcinoma;
Susceptibility
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Amino Acid Substitution;
Asian Continental Ancestry Group/*genetics;
Case-Control Studies;
DNA-Binding Proteins/*genetics;
Female;
Genetic Predisposition to Disease;
Genotype;
Humans;
Male;
Middle Aged;
Odds Ratio;
Polymorphism, Single Nucleotide;
Republic of Korea;
Risk Factors;
Thyroid Neoplasms/*genetics
- From:Journal of Korean Medical Science
2011;26(8):991-995
- CountryRepublic of Korea
- Language:English
-
Abstract:
Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers. We analyzed the relationship between XRCC1 polymorphisms and the risk of papillary thyroid carcinoma in a Korean sample. A hospital-based case-control study was performed in 111 papillary thyroid carcinoma patients and 100 normal control subjects. XRCC1 Arg194Trp and Arg399Gln single nucleotide polymorphisms (SNPs) were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). The XRCC1 Arg194Trp Arg/Trp genotype was significantly associated with a decreased risk of papillary thyroid carcinoma compared to that of Arg/Arg genotype (odds ratio [95% confidence intervals]; 0.550 [0.308-0.983]). There was no significant association between XRCC1 Arg399Gln genotypes and risk of papillary thyroid carcinoma. Based on these results, the XRCC1 Arg194Trp Arg/Trp genotype could be used as a useful molecular biomarker to predict genetic susceptibility for papillary thyroid carcinoma in Koreans.
