Progress of the talin and the mechanical basis theory of memory
10.16098/j.issn.0529-1356.2023.02.019
- Author:
Hui-Zhu CHEN
1
;
Xuan FANG
2
;
Chang-Yu TAO
2
;
Wei-Guang ZHANG
2
Author Information
1. Peking University Health Science Center
2. Department of Human Anatomy and Histology and Embryology, School of Basic Medicine, Peking University Health Science Center
- Publication Type:Journal Article
- Keywords:
Computers;
Memory;
MeshCODE theory;
Synapses;
Talin
- From:
Acta Anatomica Sinica
2023;54(2):249-254
- CountryChina
- Language:Chinese
-
Abstract:
Memory loss induced by aging and hypoxia is very common, so exploring the mechanism of memory production, storage and retrieval is of great significance to daily life and clinical work. The storage and retrieval of memory is probably similar to the computer. We summarized the research progress of MeshCODE theory, the mechanical basis of memory. Memory loss in certain diseases (such as Alzheimer's disease) or pathological conditions (such as aging, lack of oxygen) may be associated with abnormal folding of talin, a mechanosensitive protein. It can dynamically regulate synaptic activity by changing the state of the domain, storing or updating information about small changes in mechanical forces in binary form, and initiating chemical processes such as ligand redistribution in neurons, so that memory is stored in the brain in a binary format, known as the MeshCODE theory.
