Glucose and serum deprivation under hypoxia treatment inducing oxidative stress and apoptosis in rat bone marrow mesenchymal stem cells through inhibition of Nrf2 signaling pathway
10.16098/j.issn.0529-1356.2023.03.008
- Author:
Qiu-Min XIE
1
;
Yan-Ting SUN
1
;
Hui-Wen LIU
1
;
Qin YI
1
;
Bin TAN
1
;
Jing ZHU
1
;
Hao XU
2
;
Jie TIAN
3
Author Information
1. Department of Pediatric Research Institute, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics
2. Department of Clinical Laboratory, Children's Hospital of Chongqing Medical University
3. Department of Cardiovascular (Internal Medicine), Children's Hospital of Chongqing Medical University
- Publication Type:Journal Article
- Keywords:
Bone marrow mesenchymal stem cell;
Glucose and serum deprivation under hypoxia;
Oxidative stress;
Rat;
Western blotting
- From:
Acta Anatomica Sinica
2023;54(3):305-312
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of glucose and serum deprivation under hypoxia(GSDH)treatment on oxidative stress and apoptosis in rat bone marrow mesenchymal stem cells (BMSCs), so to provide an experimental support for improving the therapeutic efficacy of BMSCs. Methods The cell injury model was established by hypoxia (1% O
