Research progress of α7 nicotinic acetylcholine receptors in central nervous system diseases
10.12092/j.issn.1009-2501.2021.09.013
- Author:
Wenxiang FAN
1
;
Chi XU
2
;
Jinlu ZHANG
3
Author Information
1. Clinical Trials Institute, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health
2. Department of Neurobiology and Acupuncture Research, The 3rd Clinical College, Zhejiang Chinese Medical University
3. School of Medicine, Southeast Universitym
- Publication Type:Journal Article
- Keywords:
Alzheimer's disease;
Central nervous system diseases;
Parkinson's disease;
Stroke;
α7 nAChR
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2021;26(9):1065-1072
- CountryChina
- Language:Chinese
-
Abstract:
Alpha-7 nicotinic acetylcholine receptors (α7 nAChRs) are expressed in the central nervous system (CNS) and are thought to play a role in a wide variety of psychiatric and neurological disorders. Activation of α7 nAChR leads to an anti-inflammatory effect, which may show beneficial effects in those central nervous system disorders. In the present article, we summarize information on receptor distribution and expression, and review the effects of α7 nAChR on the CN disorders (e.g., Alzheimer's disease, Parkinson's disease, and stroke), which may provide a new idea for the development of the treatment of CNS diseases.
