Experimental study of schisandrin B attenuates acute myocardial ischemia injury in rats by inhibiting cardiomyocyte apoptosis
10.12092/j.issn.1009-2501.2022.08.002
- Author:
Haiyan HUA
1
;
Jie YAN
2
;
Yufen QIN
3
Author Information
1. Department of Health Medicine, The 903rd Hospital of PLA Joint Logistic Support Force
2. Department of Respiratory Gastroenterology, The 93rd Hospital of JOINT Logistic Support Force
3. Department of Pharmacy, Huzhou Hospital of Traditional Chinese Medicine
- Publication Type:Journal Article
- Keywords:
apoptosis;
myocardial ischemia reperfusion injury;
oxidative stress;
schisandrin B
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(8):848-856
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To explore the protective effect and mechanism of schisandrin B (Sch B) on myocardial ischemia-reperfusion injury (MIRI) in rats. METHODS: Forty SD rats were randomly divided into control group, MIRI group, MIRI +30 mg/kg Sch B (MIRI + L-Sch B) group and MIRI +60 mg/kg Sch B (MIRI + H-Sch B) group, ten in each group, Sch B were intragastrically for 7 days. Ligation of the left anterior descending branch was used to establish MIRI model, control group rats only underwent sham operation. The ardiac function parameters of ejection fraction (EF), fractional shortening (FS), maximum rate of increase in left ventricular pressure (+ dp/dt
