Research progress of autophagy in intestinal ischemia-reperfusion injury
10.12092/j.issn.1009-2501.2022.09.014
- Author:
Wei ZHANG
1
;
Yingbin WANG
1
;
Lu CAO
1
;
Yan LIU
1
;
Li ZHANG
1
;
Jieting LIU
1
Author Information
1. Department of Anesthesiology, Lanzhou University Second Hospital
- Publication Type:Journal Article
- Keywords:
autophagy;
intestinal ischemia-reperfusion injury;
molecular mechanism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2022;27(9):1061-1066
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal ischemia/reperfusion injury (ll/RI) is a common pathological process in clinical practice. Ischemia/reperfusion causes damage to intestinal mucosa and distant organs, and induces systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Autophagy is a defense regulation mechanism under stress conditions, which can maintain the homeostasis of cytoplasm, proteins and organelles. The mechanism of autophagy is complex, which is Intestinal ischemia/reperfusion injury (II/RI) is a common pathological process in clinical practice. Ischemia/reperfusion causes damage to intestinal mucosa and distant organs, and induces systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Autophagy is a defense regulation mechanism under stress conditions, which can maintain the homeostasis of cytoplasm, proteins and organelles. The mechanism of autophagy is complex, which is co-regulated by protein complexes encoded by evolutionarily conserved autophagy-related gene (ATG) and a variety of signaling molecules and pathways. Studies have found that autophagy is involved in the process of intestinal ischemia-reperfusion injury. Therefore, revealing the mechanism of autophagy in II/RI can provide evidence for the prevention and treatment of II/RI.
