Advances in venlafaxine-related PK-PD relationship and influencing factors
10.12092/j.issn.1009-2501.2023.07.010
- Author:
Xin WANG
1
;
Guodong WU
2
;
Ming AN
2
;
Gang LI
2
;
Yang LIU
2
Author Information
1. Baotou Medical College, Inner Mongolia University of Science&Technology
2. Inner Mongolia Medical University
- Publication Type:Journal Article
- Keywords:
influencing factors;
P450 enzyme;
PK-PD;
venlafaxine
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2023;28(7):788-795
- CountryChina
- Language:Chinese
-
Abstract:
Venlafaxine (VEN) is a new antidepressant drug that can effectively antagonize the reuptake of serotonin (5-HT) and norepinephrine (NE), compared with other antidepressants, venlafaxine pharmacokinetics / pharmacodynamics (PK-PD) is more regular and has the characteristics of less toxic side effects, fast oral absorption, and high bio-availability. This article reviews the PK-PD model-ling of venlafaxine and its quantitative relationship, as well as the factors affecting the process in vivo of venlafaxine, including sex, body weight, individual genotype, liver and kidney function impairment, drug-drug interaction and other related factors.
