Bioch A inhibits LPS-induced microglial activation through estrogen receptors and its mechanism

Author: Meng-Qing LIU ¹ ; Yang-Yang WU ¹ ; Jun-Hui HAN ¹ ; Yi-Gui YU ¹ ; Wen-Ning WU ¹ ; Wei-Zu LI ¹ ; Yan-Yan YIN ¹ ; Han-Qing CHEN ²
Author Information

1. Dept of Pharmacology, School of Basic Medicine, Anhui Medical University
2. School of Food Science and Engineering, Hefei University of Technology
Publication Type:Journal Article
Keywords: Bioch A; estrogen receptor; lipopolysaccharide; MAPK; microglia
From: Chinese Pharmacological Bulletin 2021;37(6):809-814
CountryChina
Language:Chinese
Abstract: Aim To investigate whether the effect of biochanin A (biochanin, Bioch A) on LPS-induced microglia activation can be inhibited by estrogen receptor. Methods The BV2 cells were divided into: Control group, LPS group (10 mg · L