Study on molecular mechanism of circulating tumor cell clusters promoting hematogenous metastasis
10.3969/j.issn.1001-1978.2021.05.003
- Author:
Yang LIU
1
;
Qian ZHENG
1
;
Xiu-Qin ZHENG
1
;
Hui FAN
1
;
Yin LU
1
;
Ai-Yun WANG
1
;
Wen-Xing CHEN
1
Author Information
1. School of Pharmacy, Nanjing University of Chinese Medicine, Jiangsu Key Lab for Pharmacology and Safety Evaluation of Chinese Materia Medica
- Publication Type:Journal Article
- Keywords:
biomarker;
circulating tumor cell clusters;
clinical value;
hematogenous metastasis;
molecular mechanism;
tumor
- From:
Chinese Pharmacological Bulletin
2021;37(5):602-606
- CountryChina
- Language:Chinese
-
Abstract:
Tumor metastasis is an important cause of death in tumor patients. Once metastasis occurs, cancer will become more difficult to treat. Many studies have observed circulating tumor cells (CTCs) in the circulatory system of patients with metastasis. CTCs may occasionally appear in the form of clusters during the process of hematogenous metastasis. These aggregated tumor cell clusters have higher efficacy than the single CTC. The development of circulating tumor cell cluster capture technology provides new insights into tumor metastasis. The molecular mechanism of CTC clusters formation and their role in tumor hematogenous metastasis are discussed here, and their use as biomarkers and target in therapy is evaluated.
