Study on protective effect of pedunculoside on acute myocardial ischemia/reperfusion injury in rats
- Author:
Ai-Ping YANG
1
;
Qi-Chun ZHANG
1
;
Yi SONG
1
;
Meng YANG
1
;
Jun-Yang WANG
1
;
Chang WANG
1
;
Li-Hong HU
1
;
Xia-Chang WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: electrocardiogram; hemodynamics; markers of myocardial injury; myocardial ischemic/reperfusion injury; pedunculoside; rats
- From: Chinese Pharmacological Bulletin 2021;37(4):484-489
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the protective effect of pedunculoside (PE) on myocardial ischemia/reperfusion injury. Methods Rat model of acute myocardial ischemia reperfusion injury was prepared by ligating the left anterior descending coronary artery (LAD) of the heart for 30 min and reperfusion for 24 h, and the rats were randomly divided into seven groups (re = 10): sham group (Sham), acute myocardial ischemia reperfusion injury model group (M), captopril group (Capt), metoprolol group (MT), PE low, medium and high dosage groups (2. 5, 5 and 10 mg · kg
