Bicyclol alleviates fulminant liver injury induced by TNF-α/D-GalN via inhibiting the mitochondrial apoptosis pathway

Author: Hu LI ¹ ; Jian-Rui LI ¹ ; Nan-Nan LIU ¹ ; Mei-Xi WANG ¹ ; Jia-Li TAN ¹ ; Zong-Gen PENG ¹
Author Information

1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College
Publication Type:Journal Article
Keywords: apoptosis; bicyclol; hepatitis; liver injury; mitochondria; tumor necrosis factor-α
From: Chinese Pharmacological Bulletin 2021;37(4):478-484
CountryChina
Language:Chinese
Abstract: Aim To investigate the protective effect of bicyclol on tumor necrosis factor-α/D-galactosamine (TNF-α/D-GalN) induced liver injury and its possible mechanisms. Methods Male C57 mice were given 50, 100, and 200 mg · kg