Effects of RCE-4, an active component of Reineckia carnea, on regulation of cell cycle arrest in human cervical cancer Ca Ski cells by triggering endoplasmic reticulum stress

Author: Li-Yun MOU ¹ ; Xiang-Fei XING ¹ ; Gui-Lan JIN ¹ ; Wei XI ¹ ; Li-Yun MOU ² ; Chong-Xu CHEN ³ ; Jing ZHANG ³ ; Jian-Feng CHEN ³
Author Information

1. Dept of Pharmacy, The People's Hospital of Three Gorges University, The First People's Hospital of Yichang
2. Medical College, Three Gorges University
3. Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences of China, Three Gorges University
Publication Type:Journal Article
Keywords: cell cycle arrest; cell proliferation; cervical cancer; endoplasmic reticulum stress; RCE-4; Reineckia carnea
From: Chinese Pharmacological Bulletin 2021;37(9):1224-1231
CountryChina
Language:Chinese
Abstract: Aim: To explore the mechanism of RCE-4, an active constituent isolated from Reineckia carnea on anti-proliferation activity of human cervical neoplasm Ca Ski cells. Methods Etramethylazolyl blue method (MTT) and clone formation assay were adopted to observe the inhibitory effects of RCE-4 on the growth of Ca Ski cells, and its half maximal inhibitory concentration (IC