Role of β-adrenergic receptors in development of breast cancer

Author: Li SONG ¹ ; Xiao-Bin DAI ¹ ; Qi JIA ¹ ; Yin-Yin ZHOU ¹ ; Xiao-Man LI ¹ ; Yuan-Yuan WU ¹ ; Wen-Xing CHEN ¹ ; Ai-Yun WANG ¹ ; Yin LU ¹ ; Wen-Xing CHEN ² ; Ai-Yun WANG ² ; Yin LU ²
Author Information

1. Jiangsu Key Lab for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy
2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine
Publication Type:Journal Article
Keywords: Breast cancer; Catecholamine; Stress; Tumor progression; β-adrenergic receptor blockers; β-adrenergic receptors
From: Chinese Pharmacological Bulletin 2021;37(3):309-313
CountryChina
Language:Chinese
Abstract: ; β-adrenergic receptors (β-ARs) are widely found in organs of the human body and play an important role in regulating heart function, blood vessel dilation, energy metabolism, etc. Studies have shown that β-ARs are abnormally high in breast cancer cells, which can promote the occurrence and development of breast cancer by affecting the growth and metabolism of breast cancer, invasive metastasis, and angiogenesis. Clinical studies have shown that blocking β-ARs signaling improves the prognosis of breast cancer patients, so β-ARs may be a potential treatment target for breast cancer. This paper summarizes the role of β-ARs in the development of breast cancer, with a view to providing some reference for follow-up research and clinical treatment.