Research progress on the role of immune cells in tumor hematogenous metastasis
10.3969/j.issn.1001-1978.2021.12.006
- Author:
Yu TANG
1
;
Wei-Wei ZHENG
1
;
Cheng QIAN
1
;
Shan ZHANG
1
;
Chun-Mei YANG
1
;
Fei-Hui WANG
1
;
Yin LU
1
;
Ai-Yun WANG
1
;
Yin LU
2
;
Ai-Yun WANG
2
Author Information
1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine
2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
antiangiogenic herapy;
immune cells;
tumor blood metastasis;
tumor blood vessels;
tumor immunotherapy;
tumor lymphatic vessels
- From:
Chinese Pharmacological Bulletin
2021;37(12):1653-1658
- CountryChina
- Language:Chinese
-
Abstract:
Tumor blood and lymphatic vessel growth are necessary conditions for tumor growth, progression and metastasis, which are closely related with infiltrating nnate as well as adaptive immune cells. On one hand, immune cells rely on adhesion molecules on vascular endothelial cells to penetrate into tumor tissues and show anti-tumor characteristics. On the other hand, they can regulate tumor angiogenesis and lymphangiogenesis by secreting chemokines and cytokines, playing an important role in the process of tumor blood metastasis. In addition, the role of immune cells in promoting tumor blood metastasis highlights the shortcomings of t anti-angiogenic therapy. Therefore, targeting immune cells and tumor angiogenesis improve the effect of therapeutic. Based on these, this article summarizes the effects of immune cells on blood and lymphatic vessels n tumor metastasis, as well as related anti-vascular and immune therapies, in order o provide deas for subsequent research.
