Dexmedetomidine protects acute myocardial ischemic injury in rats by inhibiting TXNIP

Author: Sheng-Nan LIU ¹ ; Li-Jun XIE ¹ ; Yuan WANG ² ; Jiao-Jiao MA ³ ; Na HAO ⁴ ; Hong JIANG ⁴ ; Li-Ping LI ⁴ ; Qin-Zeng ZHANG ⁴ ; Li-Jun XIE ⁴
Author Information

1. College of Clinical Medicine, Hebei University
2. Institute of Traditional Chinese Medicine, Chengde Medical College
3. Dept of Endocrinology, First Hospital, Hebei Medical University
4. Institute of Materia Medica, Hebei Academy of Medical Sciences
Publication Type:Journal Article
Keywords: acute myocardial ischemia; apoptosis; Dexmedetomidine; H; TRX; TXNIP
From: Chinese Pharmacological Bulletin 2022;38(12):1823-1830
CountryChina
Language:Chinese
Abstract: Aim To investigate the protective effect of dexmedetomidine(DEX)on acute myocardial ischemia in rats and its mechanism.Methods Sixty SD rats were randomly divided into five groups: control group(C), model group(M), and dexmedetomidine 10, 25, 50 μg·kg