Advances in effect of peroxisome proliferators-activated receptors in ischemic stroke

Author: Yu-Jia WU ¹ ; Jian-Mei GAO ¹ ; Qi-Hai GONG ¹ ; Jian-Mei GAO ² ; Qi-Hai GONG ²
Author Information

1. Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education
2. School of Pharmacy.Zunyi Medical University
Publication Type:Journal Article
Keywords: apoptosis; auto¬phagy; ischemic stroke; oxidative stress; peroxisome proliferation-aetivated reeeptors: neuroinflanimation
From: Chinese Pharmacological Bulletin 2022;38(5):655-659
CountryChina
Language:Chinese
Abstract: Ischemic stroke(IS)is one of the leading causes of mortality and disability with a high incidence and recurrence rate.However, effective therapy for treating IS is still unavailable in clinic.Peroxisome proliferation-activated receptors(PPARs)is a type of ligand-activated nuclear transcription factors that play a key role in a variety of biological processes.PPARs are close to IS, hence this study reviews that PPARs exerts the protective effect on IS through mediating neuroinflammation, oxidative stress, apoptosis, autophagy, demyelination, blood brain barrier function, encephaledema and lactic acid metabolism, which hopes to provide novel strategies for the prevention and treatment of IS.