Progress in RIPK3-mediated necroptosis involved in myocardial ischemia-reperfusion injury

Author: Su-Yue YIN ¹ ; Shou-Bao WANG ¹ ; Guan-Hua DU ¹
Author Information

1. Beijing Key Lab of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College
Publication Type:Journal Article
Keywords: cardiac disease; cell death; inflammation; myocardial ischemia-reperfusion injury(MIRI); necroptosis; RIPK3
From: Chinese Pharmacological Bulletin 2022;38(5):641-644
CountryChina
Language:Chinese
Abstract: Aim Timely re establishment of coronary blood How in patients with myocardial infarction is the cornerstone of their treatment; however, substantial amount of damage can oecur as a consequence of reperfusion.In recent years it has been found that receptor interacting protein kinase 3 ( RIPK3 ) contributes remarkably to myocardial ischemia-reperfusion injury (MIRI).RIPK3 can regulate necroptosis through RIPK1/RIPK3/MLKL and CaMKII, respectively, and participate in the MIRI process.This artiele reviews the researeh progress of RIPK3-mediated ne¬ croptosis involved in MIRI from endoplasmic reticulum stress, mitochondrial fragmentation disturbanee, cardiac microvascular dysfunction and inflammation, and focuses on whether RIPK3 can be used as a new target for anti-MIRI, so as to provide a new strategy and choice for improving the clinical treatment effect and prognosis of ischemic heart disease.