Research on efficacy-toxicity of Tripterygium wilfordii Hook.F.In treatment of lupus nephritis based on network pharmacology
10.3969/j.issn.1001-1978.2022.02.021
- Author:
An-Ping SHEN
1
;
Bing-Sen WANG
1
;
Huan LI
2
;
Xiao-Kun LI
3
;
Song-Wei LI
4
Author Information
1. Graduate School
2. First Affiliated Hospital of Henan University of Chinese Medicine
3. School of Pharmacy, Ilenan University of Chinese Medicine
4. Second Afficiated Hospital of Henan University of Chinese Medicine
- Publication Type:Journal Article
- Keywords:
efficacy-toxicity;
lupus nephritis;
mechanism;
network pharmacology;
signaling pathway;
Tripterygium wilfordii Hook.f.
- From:
Chinese Pharmacological Bulletin
2022;38(2):275-281
- CountryChina
- Language:Chinese
-
Abstract:
Aim To explore the efficacy-toxicity of Tripterygium wilfordii Hook.f.in intervention of lupus nephritis by the method of network pharmacology.Methods Firstly, the active components were searched and the action targets of Tripterygium wilfordii Hook.f.were predicted through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP).Secondly, the target genes of LN were collected through CoolGeN, OMIM and Gene Cards databases.And then, it was mapped to Tripterygium wilfordii Hook.f.targets and the drug component-disease target interaction network was constructed with Cytoscape software, and STRING database was used to analyze the protein interaction network.Finally, the common targets were analyzed by GO and KEGG pathway enrichment analysis using DAVID database to explore the potential mechanism of Tripterygium wilfordii Hook.f.in the treatment of LN.Results A total of 52 active components of Tripterygium wilfordii Hook.f.and 38 targets for the treatment of LN were screened.Most of the components had potential therapeutic effects on LN, but the effects of triptolide, tripterine, kaempferol and β-sitosterol may not be conducive to the improvement of LN.The results of KEGG analysis showed that efficacy-toxicity mainly involved NOD-like receptor signaling pathway, p53 signaling pathway, Toll-like receptor signal pathway and so on.Conclusions Tripterygium wilfordii Hook.f.plays the efficacy-toxicity effect on LN by regulating immune inflammation, cell proliferation and apoptosis, and its overall intervention effect needs further experimental study.
