Development of natural products in prevention and treatment of osteoporosis based on GSK-3fJ signaling pathway

Author: Yan-Ting ZHONG ¹ ; Ya-Jun YANG ¹ ; Hong-Bo UAO ¹ ; Yan-Ting ZHONG ² ; Liao GUI ² ; Jia-Xiao LI ³
Author Information

1. School of Pharmacy, Dept of Pharmacology
2. Guangdong Key Ixib for Research and Development of Nature Drugs .Guangdong Medical University
3. South China University of Technology
Publication Type:Journal Article
Keywords: mechanist to Settings to activate Windows; natural I^tw^te^WWfovh?110 metabo¬lism; osteoporosis; plants
From: Chinese Pharmacological Bulletin 2022;38(6):817-821
CountryChina
Language:Chinese
Abstract: Abnormality of glycogen synthase kinase-3 (3 ( GSK- 3(i) triggers a deleterious consequence of disorder of bone me¬tabolism , contributing to osteoporosis.Osteoporosis is character¬ized by bone loss and destruction of bone microstmcture, which often leads to the increase of incidence rate of fracture.Natural products derived from plants can be used as potential dmgs to prevent and treat osteoporosis.In this review, we elaborates on the intimate connection between GSK-3p and bone metabolism.and summarizes natural products of flavonoids, isoflavoncs, pol¬ysaccharides and saponins, phenols, alkaloids and amine deriv¬atives regulating GSK-3(3 pathway in the prevention and treat¬ment of osteoporosis, which may provide scientific evidence for further development of drugs that may effectively prevent and treat osteoporosis.