The protective effect of betelnut polyphenols on exercise-induced fatigue at high altitude and its network pharmacology in rats

Author: Yue-Mei SUN ¹ ; Xing-Yu HAN ¹ ; Jiang-Hong MA ¹ ; Jun-Fei CHENG ¹ ; Rong WANG ¹ ; Wen-Bin LI ¹
Author Information

1. Dept of Pharmacy, The 940th Hospital of Joint Logistics Support force of Chinese People's Liberation Army, Gansu Plateau Pharmaceutical Technology Center
Publication Type:Journal Article
Keywords: betelnut polyphenols; exercise fatigue; network pharmacology; oxidative stress; plateau; treadmill
From: Chinese Pharmacological Bulletin 2023;39(10):1966-1972
CountryChina
Language:Chinese
Abstract: Aim: To explore the protective effect of betelnut polyphenols on high altitude exercise-induced fatigue in rats, and to select the main targets to carry out network pharmacology research to preliminarily explore its protective mechanism. Methods: We compared the protective effects of areca catechu polyphenols on high altitude exercise fatigue in rats in low, medium and high dose groups (400, 800, and 1600 mg·kg