Regulation of Dracocephalum Moldavica total flavonoids on foaming and inflammatory response of RAW264. 7 maerophages

Author: Chun-Yan DU ¹ ; Xu-Li RUAN ¹ ; Yun-Li ZHAO ² ; Xin-Chun WANG ² ; Wen-Jiang CAO ²
Author Information

1. Dept of Pharmacy, College of Pharmacy, Shihezi University
2. Dept of Pharmacy, The First Affiliated Hospital of the Medicai College, Shihezi University
Publication Type:Journal Article
Keywords: atherosclerosis; Dracocephalum Moldavica total flavonoids; foam cells; inflammatory response; maerophages; NF-KB
From: Chinese Pharmacological Bulletin 2023;39(10):1973-1979
CountryChina
Language:Chinese
Abstract: Aim To investigate the effeets of Dracocephalum Moldavica total flavonoids (TFDM) on the foaming lipoprotein (ox-LDL), and to further elucidate the mechanism of anti-atherosclerosis (AS) of TFDM. Methods RAW264. 7 maerophages were cultured in vitro and induced to become foam cells by ox-LDL stimulation, and inflammation of mouse monocyte macrophage leukemia cells (RAW264. 7) induced by oxi-dized low density TFDM(25, 50, 100 mg • L"