Total salvianolic acid combined with anti-PD-Ll inhibits development of breast cancer by regulating infiltration of myeloid macrophages

Author: Meng-Yao SONG ¹ ; Cheng QIAN ¹ ; Yin LU ¹ ; Yin LU ²
Author Information

1. Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy
2. Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine (TCM) Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine
Publication Type:Journal Article
Keywords: anti-PD-Ll; breast cancer; immunotherapy; modernization of traditional Chinese medicine; myeloid macrophages; total salvianolic acid
From: Chinese Pharmacological Bulletin 2023;39(10):1884-1890
CountryChina
Language:Chinese
Abstract: Aim To explore the effect of total salvianolic acid (TSA) combined with anti-PD-Ll on the development of breast cancer by inhibiting the infiltration of myelogenous macrophages into tumors. Methods E0771 breast cancer subeutaneous tumor model was constructed. Twenty-five mice were randomly divided into control group, model group, total salvianolic acid group (TSA 10 g • kg