Research progress of AMPK regulating ferroptosis related signaling pathway

Author: Feng WANG ¹ ; Wen-Xiu QIN ¹ ; Qi WANG ¹ ; Zhen-Ting DENG ¹
Author Information

1. First Teaching Hospital of Tianjin University of Traditional Chinese Mediane, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion
Publication Type:Journal Article
Keywords: AMPK; diseases; ferroptosis; mechanis-mof action; pathway ' s interaction; signaling pathways
From: Chinese Pharmacological Bulletin 2023;39(10):1801-1805
CountryChina
Language:Chinese
Abstract: Energy imbalance is eonsidered an important driver of human diseases. As an important energy sensor, AMPK plays a central role in maintaining energy homeostasis, making it a key target for disease prévention and treatment. As a new type of cell death, ferroptosis is related to the pathophysiologieal process of many diseases, and AMPK-related signaling pathway is an important way to regulate iron death. Understanding which pathway AMPK induces or inhibits ferroptosis will provide new ideas for the treatment of diseases in the future and provide new targets for new drug research. In this paper, we review the related litera-tures and explore the signaling pathways of AMPK regulating ferroptosis, wïth a brief description of the application of AMPK-mediated ferroptosis related signaling pathways in diseases, hoping to provide reference for later research.