Effects of ethanolic extracts of Euonymus alatus on CCl

Author: Yong-Lan WANG ¹ ; Bo-Nan TAO ¹ ; Ming-Huan CHEN ¹ ; Hua-Hua ZENG ¹ ; Min MA ¹ ; De-Bin HUANG ¹
Author Information

1. Hubei Minzu University, Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases
Publication Type:Journal Article
Keywords: ethanolic extracts of Euonymus alatus; hepatic fibrosis; IL-6; JAK2; STAT3; TNF-α
From: Chinese Pharmacological Bulletin 2023;39(5):875-883
CountryChina
Language:Chinese
Abstract: Aim To explore the mechanism of ethanolic extracts of euonymus alatus on CCl4-induced hepatic fibrosis in mice by regulating JAK2/STAT3 signaling pathway. Methods Sixty C57BL/6J mice were randomly divided into control group,model group,EAL,EAM),EAH,and Silybin(n=10). Except for the control group,mice in other groups were injected with 25% CCl4 of 1.6 mL·kg