Ginsenoside Rg1 attenuates palmitate-induced HMCs fibrosis by inhibiting NOX4/MAPK pathways

Author: Hui-Min ZHOU ¹ ; Jie ZHANG ¹ ; Lei HUANG ¹ ; Ran SUN ¹ ; Peng-Min JI ¹ ; Liang-Liang KONG ¹ ; Wei-Zu LI ¹ ; Wei-Ping LI ¹
Author Information

1. Dept of Pharmacology, School of Basic Medical Sciences, Anhui Medical University
Publication Type:Journal Article
Keywords: fibrosis; ginsenoside Rg1; human glomerullar mesangial cells; MAPK; NADPH oxidases 4; sodium palmitate
From: Chinese Pharmacological Bulletin 2023;39(5):917-925
CountryChina
Language:Chinese
Abstract: Aim To investigate the inhibitory effect of ginsenoside Rg1 on sodium palmitate induced fibrosis in human glomerullar mesangial cells (HMCs) and its mechanism. Methods (1) HMCs were treated with different concentrations of PA for 24 h, the intracellular lipid accumulation was observed by oil red staining, and the intracellular ROS production was detected by H2DCFDA kit; (2) HMCs were divided into control, PA (160 μmol·L