Digoxin alleviates pulmonary fibrosis by inhibiting macrophage M2 polarization via regulating mTORC2-IRF4 signaling pathway

Author: Miao YANG ¹ ; Xiao-Feng MEI ¹ ; Li-Dan JIA ¹ ; Xin-Rong TIAN ¹ ; Miao-Miao YAN ¹ ; Xue MEI ¹ ; Peng ZHAO ¹ ; Xue-Fang LIU ¹ ; Miao YANG ² ; Xiao-Feng MEI ² ; Li-Dan JIA ² ; Xin-Rong TIAN ² ; Miao-Miao YAN ² ; Xue MEI ² ; Peng ZHAO ² ; Xue-Fang LIU ² ; Peng ZHAO ³ ; Xue-Fang LIU ³
Author Information

1. Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P. R. China, Henan University of Chinese Medicine
2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine
3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine
Publication Type:Journal Article
Keywords: digoxin; IRF4; M2 polarization; macrophages; mTORC2; pulmonary fibrosis
From: Chinese Pharmacological Bulletin 2023;39(4):707-715
CountryChina
Language:Chinese
Abstract: Aim To investigate the protective effect of digoxin (Dig) on the bleomycin (BLM)-induced pulmonary fibrosis in mice and the underlying mechanism. Methods Pulmonary fibrosis model was established by intratracheal instillation of BLM (5 mg · kg