Effect of cangfudaotan decoction on TLR4/NF-κB p65 signaling pathway in obese PCOS-IR rats
- Author:
Hai-Yan XU
1
;
Qing DU
1
;
Juan CHEN
1
;
Hong-Mei WANG
1
;
Xiao-Ning TAN
1
Author Information
- Publication Type:Journal Article
- Keywords: Cangfudaotan Decoction; chronic inflammation; insulin resistance (IR); nuclear transcription factor-κB p65(NF-κB p65); polycystic ovary syndrome (PCOS); Toll-like receptor 4 (TLR4)
- From: Chinese Pharmacological Bulletin 2023;39(4):787-793
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the regulatory effect of Cangfudaotan Decoction on the ovarian Toll receptor 4 (TLR4)/nuclear transcription factor kBp65 (NF-κB p65) signaling pathway in obese PCOS-IR rats. Methods Forty-eight female rats were randomly divided into normal group (n = 8) and model group (n = 40). The obese PCOS-IR rats were established by letrozole (1 mg · kg
