Baicalin inhibits streptozotocin-induced neuroinflammation in Alzheimer' s disease rat model by TLR4/MyD88/NF-κB pathway

Author: Wen-Jing YU ¹ ; Miao YANG ¹ ; Chun-Xiang HE ¹ ; Yi-Jie JIN ¹ ; Ze LI ¹ ; Ping LI ¹ ; Si-Si DENG ¹ ; Shao-Wu CHENG ¹ ; Zhen-Yan SONG ¹
Author Information

1. Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio-Cerebral Diseases, Hunan University of Chinese Medicine
Publication Type:Journal Article
Keywords: Alzheimer' s disease; baicalin; MyD88; neuroinflammation; NF-K B; streptozo; TLR4; tocin
From: Chinese Pharmacological Bulletin 2023;39(1):83-89
CountryChina
Language:Chinese
Abstract: Aim To investigate the effects of baicalin on the inflammatory response and Toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD 88)/nuclear factor kappa B (N F-K B) signaling pathway in Alzheimer' s disease (AD) rat model induced by lateral ventricular injection of streptozotocin (STZ). Methods The AD animal model was constructed by lateral ventricular injection of STZ in SD rats, and divided into sham operation group, model group, low-dose (60 mg