Liraglutide inhibits high glucose-induced cardiomyocyte hypertrophy via modulating autophagy and Na

Author: Zhe ZHANG ¹ ; Xing WANG ¹ ; Lin-Quan YANG ¹ ; Hui-Juan MA ¹ ; Zhan-Ying YE ²
Author Information

1. Key Laboratory of Metabolic Diseases, Hebei General Hospital
2. Third Dent of Neurosurgery, Hebei General Hospital
Publication Type:Journal Article
Keywords: autophagy; cardiomyocyte hypertrophy; diabetes mellitus; K; liraglutide; Na; Na; type 2
From: Chinese Pharmacological Bulletin 2023;39(1):43-50
CountryChina
Language:Chinese
Abstract: Aim To investigate the mechanism through which liraglutide (LRG) inhibited high glucose (HG)-induced cardiomyocyte hypertrophy. Methods Cultured H9c2 were divided into control (CON) group, HG group, low-, middle- and high-dose LRG (LRG-L, LRG-M and LRG-H) groups, LRG-H + autophagy inhibitor trimethyladenine (3-MA) group. The relative cell surface change was assessed phalloidin staining. Membrane bound Na, K