Effects of dagliflozin on atrial tachyarrhythmia in rats with pulmonary arterial hypertension related right heart failure and its mechanisms

Jin-Chun WU; Tao LIU; Bo CUI; Zhi-Xing FAN; Wei ZHANG; Jun-Miao LUO; Yan-Hong TANG; Gang WU; He HUANG; Cong-Xin HUANG; Jin-Chun WU; Tao LIU; Bo CUI; Zhi-Xing FAN; Wei ZHANG; Jun-Miao LUO; Yan-Hong TANG; Gang WU; He HUANG; Cong-Xin HUANG; Jin-Chun WU; Tao LIU; Bo CUI; Zhi-Xing FAN; Wei ZHANG; Jun-Miao LUO; Yan-Hong TANG; Gang WU; He HUANG; Cong-Xin HUANG; Jin-Chun WU

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Effects of dagliflozin on atrial tachyarrhythmia in rats with pulmonary arterial hypertension related right heart failure and its mechanisms

Author: Jin-Chun WU ¹ ; Tao LIU ¹ ; Bo CUI ¹ ; Zhi-Xing FAN ¹ ; Wei ZHANG ¹ ; Jun-Miao LUO ¹ ; Yan-Hong TANG ¹ ; Gang WU ¹ ; He HUANG ¹ ; Cong-Xin HUANG ¹ ; Jin-Chun WU ² ; Tao LIU ² ; Bo CUI ² ; Zhi-Xing FAN ² ; Wei ZHANG ² ; Jun-Miao LUO ² ; Yan-Hong TANG ² ; Gang WU ² ; He HUANG ² ; Cong-Xin HUANG ² ; Jin-Chun WU ³ ; Tao LIU ³ ; Bo CUI ³ ; Zhi-Xing FAN ³ ; Wei ZHANG ³ ; Jun-Miao LUO ³ ; Yan-Hong TANG ³ ; Gang WU ³ ; He HUANG ³ ; Cong-Xin HUANG ³ ; Jin-Chun WU ⁴
Author Information

1. Dept of Cardiology, Renmin Hospital of Wuhan University
2. Cardiovascular Research Institute, Wuhan University
3. Hubei Key Laboratory of Cardiology
4. Dept of Cardiology, Qinghai Provincial People's Hospital
Publication Type:Journal Article
Keywords: atrial tachyarrhythmia; dagliflozin; fibrosis; inflammation; pulmonary arterial hypertension; right heart failure
From: Chinese Pharmacological Bulletin 2023;39(1):29-35
CountryChina
Language:Chinese
Abstract: Aim To investigate the effects of dagliflozin (DAPA) on atrial tachyarrhythmia (AT) in rats with right heart failure (RHF) due to pulmonary arterial hypertension (PAH) and the underlying mechanisms. Methods Sixty male SD rats were randomly divided into four groups: control group (CTL group), model group (MCT group), MCT + low-dose DAPA intervention group (MCT + LD group) and MCT + high-dose DAPA intervention group (MCT + HD group). After 35 days of continuous intervention, the model and cardiac function evaluation, atrial structural remodelling assessment, inflammatory factor detection, and in vivo cardiac electrophysiology experiments were completed. Results DAPA reduced menn pulmonaryarterial pressure (mPAP) and menn right ventricular pressure (mRVP) in the model rats (P <0.05), attenuated the inflammatory response (P < 0.05), reduced right atrial fibrosis (P <0.05), reduced AT induction rate (P < 0.05) and mean atrial tachyarrhythmia duration (MATD) (P < 0.05), the extent of which was more pronounced in the high-dose DAPA intervention group. Conclusions DAPA can reduce AT susceptibility in PAH-induced RHF rats, and the mechanisms may be related to the inhibition of systemic inflammation and anti-atrial fibrosis by DAPA.