Summary of anti-inflammatory and antiviral effects of IFIT1

Author: Wei JIANG ¹ ; Cheng HUANG ¹ ; Jun LI ¹ ; Wei JIANG ² ; Xiao-Yun CHEN ² ; Ya-Fei ZHANG ² ; Yuan-Yuan WANG ²
Author Information

1. School of Pharmacy, Anhui Medical University
2. Dept of Pharmacology, The Second Hospital of Anhui Medical University
Publication Type:Journal Article
Keywords: anti-inflammation; antivirus; drug therapy; IFIT1; interferon; mechanism of action
From: Chinese Pharmacological Bulletin 2023;39(1):5-8
CountryChina
Language:Chinese
Abstract: IFIT1 is a highly inducible member of the interferon stimulating gene family (ISGs) with tetrapeptide repeats. It mainly exists in the cytoplasm and is regulated by interferon, a variety of antiviral role through a variety of mechanisms and pathways, and many viruses have evolved unique mechanisms to evade the limiting effects of IFIT1 and thus counter the body' s antiviral immunity, the unique anti-inflammatory effect of IFIT1 has been extensively studied in inflammatory diseases, Therefore, we mainly review the anti-inflammatory and antiviral effects of IFIT1 and the related mechanisms, so as to provide new therapeutic targets and ideas for the treatment of related diseases.