Aloin improves TGF-β induced renal tubular epithelial cell fibrosis by activating Nrf2

Author: Yong-Jun HUANG ¹ ; Yi LI ² ; Wei-Li WANG ² ; Wei-Li WANG ³
Author Information

1. Dept of Nephrology, Jiangbei Huang Ni Bang Hospital
2. School of Medicine, Chongqing University
3. Nephrology and Urology Center, Southwest Hospital of Army Medical University
Publication Type:Journal Article
Keywords: aloin; chronic kidney disease; Nrf2; oxidative stress; renal fibrosis; renal tubular epithelial cells
From: Chinese Pharmacological Bulletin 2023;39(3):549-554
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of aloin, an aloe extract,on fibrosis of renal tubular epithelial cells (HK-2) induced by TGF-β and the underlying molecular mechanism. Methods The experiment included a control group,TGF-β induced group,TGF-β + Aloin 50 or 100 μmol • L