Construction of a novel time-specific NLRP3 transgenic mouse model by Cre-LoxP system

Author: Xi-Yue YANG ¹ ; Yong-Ting ZHOU ¹ ; Cai-Ying YE ¹ ; Lei ZHU ¹
Author Information

1. Dept of Pharmacology, Institute of Basic Medical Sciences, School of Basic Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences
Publication Type:Journal Article
Keywords: Cre-LoxP system; genotypic identification; NLRP3 mutation; phenotypic identification; time-specific; transgenic mice
From: Chinese Pharmacological Bulletin 2023;39(3):594-598
CountryChina
Language:Chinese
Abstract: Aim To construct and identify a new time-specific NLRP3 point mutation transgenic mouse model by Cre-LoxP system. Methods Cre-LoxP system was used to generate NL-RP3