Mechanism of cucurbitacin B suppresses proliferation of hepatocellular carcinoma Huh-7 cells via inducing ferroptosis
- Author:
Ting HONG
1
;
Yi-Lei WANG
1
;
Hai-Rong ZENG
1
;
Yi YUAN
1
Author Information
- Publication Type:Journal Article
- Keywords: cucurbitacin B; ferroptosis; GPX4; hepatocellular carcinoma; proliferation; ubiquitination
- From: Chinese Pharmacological Bulletin 2023;39(4):638-645
- CountryChina
- Language:Chinese
- Abstract: Aim To study the effects of cucurbitacin B (Cu B) on proliferation of hepatocellular carcinoma Huh-7 cells and its mechanism. Methods CCK-8 was used to detect the survival rate of Huh-7 cells with different concentrations of Cu B. Huh-7 cells were treated with Cu B (0. 5, 1, 2 njnol; L
