Paeonol ameliorates hepatic inflammation and oxidative stress injury on murine with alcoholic liver injury by regulating JAK2/STAT3 signaling pathway
- Author:
Min SUN
1
;
Gui-Ming YAN
1
;
Yu-Long LIU
2
;
Ke LIU
2
;
Ling-Ling LIU
2
;
Lu-Ning ZHANG
Author Information
- Publication Type:Journal Article
- Keywords: acute alcoholic liver injury; inflammation; JAK2/STAT3 signaling pathway; oxidative stress; paeonol; silibinin
- From: Chinese Pharmacological Bulletin 2023;39(6):1078-1084
- CountryChina
- Language:Chinese
- Abstract: Aim To investigate the mechanism of action of paeonol based on JAK2/STAT3 signaling pathway to ameliorate liver inflammation and oxidative stress injury induced by acute alcohol stimulation in mice. Methods C57BL/6 mice were randomly divided into normal group, model group, silibinin group (36. 8 mg • kg
