Mechanism of isovitexin in alcoholic fatty liver based on metabolomics combined with molecular docking analysis
- Author:
Hong-Mei SU
1
;
Wu-Chang ZHU
1
;
Yuan-Yuan WEI
1
;
Yu-Shen HUANG
1
;
Si-Yun CHEN
1
;
Jin-Bin WEI
1
Author Information
- Publication Type:Journal Article
- Keywords: alcoholic fatty liver disease; glycerophospholipid metabolism; isovitexin; metabolomics; molecular docking; UPLC-Q-TOF/MS
- From: Chinese Pharmacological Bulletin 2023;39(7):1303-1311
- CountryChina
- Language:Chinese
- Abstract: Aim To explore the effects of isovitexin (IVT) on alcoholic fatty liver disease (AFLD) and its mechanism based on metabolomics and in vivo methods and combined molecular docking. Methods 8-week-old male C57BL/6J mice were randomly divided into control, model and IVT groups, with 6 mice in each group. The control group was fed with alcoholic liquid feed control feed, the model group and IVT group were fed with alcoholic liquid feed model feed, and the IVT group was fed daily gastric IVT (100 mg • kg
