Effects of plateau hypoxia on the pharmacokinetics and pharmacodynamics of atorvastatin calcium in hyperlipidemic rats

Author: Qin HUANG ¹ ; Lin LUO ¹ ; Zhao-Yan WANG ¹ ; Rong WANG ¹ ; Qin HUANG ² ; Lin LUO ² ; Wen-Bin LI ² ; Rong WANG ²
Author Information

1. College of Pharmacy, Lanzhou University
2. Department of Pharmacy, The 940th Hospital of Joint Logistics Support force of Chinese People's Liberation Army
Publication Type:Journal Article
Keywords: adverse reactions; atorvastatin; hyperlipidemia; hypoxia; pharmacodynamics; pharmacokinetics
From: Chinese Pharmacological Bulletin 2023;39(7):1227-1233
CountryChina
Language:Chinese
Abstract: Objective To study the effect of simulated high altitude hypoxia on the pharmacokinetics and pharmacodynamics of atorvastatin calcium in hyperlipidemia rats. Methods The wistar rats with hyperlipidemia induced by high-fat diet were divided into normoxia group and hypoxia group. Rats in the hypoxia group received a 14-day chronic hypoxia exposure at simulated an altitude of 5, 500 m. The two groups were given atorvastatin calcium(20 mg•kg