Mechanism of heroin promoting addiction and relapse in progeny of male rats by inhibiting promoter methylation of imprinted gene H19 by down-regulating DNMT3a

Author: Ming-Ren XIE ¹ ; Tian-Xiao HE ¹ ; Xian-Xian WANG ¹ ; Liu-Yang XIE ¹ ; Xia YUAN ¹ ; Jing ZHANG ¹
Author Information

1. Public Security Branch, Gansu University of Political Science and Law, Key Laboratory of Evidence of Science and Technology Research and Application
Publication Type:Journal Article
Keywords: addiction; DNMT3a; H19; heroin; methylation; relapse
From: Chinese Pharmacological Bulletin 2023;39(8):1515-1521
CountryChina
Language:Chinese
Abstract: Aim To investigate the effect of heroin use in male rats of F0 generation on heroin addiction and relapse in rats of Fl generation and the underlying mechanism. Methods Male rats of F0 generation were treated with different doses of heroin (1, 3, 9 mg • kg