Recent advances of DJ-1 regulating mitochondrial function

Xiao-Chen NI; Shi-Long YU; Yan-Qing LIU; Xiao-Chen NI; Feng JIN

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Recent advances of DJ-1 regulating mitochondrial function

Author: Xiao-Chen NI ¹ ; Shi-Long YU ¹ ; Yan-Qing LIU ¹ ; Xiao-Chen NI ² ; Feng JIN ³
Author Information

1. The State Administration of Traditional Chinese Medicine, Key Laboratory of Toxic Pathogens-Based Therapeutic Approaches of Gastric Cancer, College of Medicine, Yangzhou University
2. Yangzhou Hospital of Traditional Chinese Medicine
3. Affiliated Hospital of Yangzhou University
Publication Type:Journal Article
Keywords: calcium signal; DJ-1; mitochondria; mitochondria-associated endoplasmic reticulum membranes; mitophagy; oxidative stress
From: Chinese Pharmacological Bulletin 2023;39(8):1406-1411
CountryChina
Language:Chinese
Abstract: Dj-l is a protein encoded by PARK7 gene, a member of the peptidase C56 protein family. Defects in PARK7 gene may lead to autosomal recessive early-onset Parkinson ' s disease. Dj-1 is a multifunctional protein that acts as an active androgen receptor-mediated transcriptional regulator, a REDOX sensitive molecular chaperone, an oxidative stress sensor, and it also protects neurons from oxidative stress and cell death. In addition, DJ-1 is also associated with mitochondria, energy metabolism, mitochondrial homeostasis, mitophagy mitochondria-associated endoplasmic reticulum membranes and other life processes. However, the precise function of DJ-1 protein is not well understood. This paper reviews the effect, mechanism and molecular basis of DJ-1 protein in regulating mitochondrial function, and discusses its potential value in combination with clinical diseases. It has good timeliness, necessity, innovation and science, and also helps to provide new targets and ideas for clinical drug development.