corilagin protects non-alcoholic fatty liver disease in mice induced by high fat and high sugar diet via regulating AMPK-autophagy signaling

Author: Jing-Ying WANG ¹ ; Hui CAO ¹ ; Ning TONG ¹ ; Ming-Deng YE ¹ ; Fei YU ¹ ; Hong-Mei DU ² ; Ming CHEN ²
Author Information

1. Dept of Pharmacy, The Second Hospital of Nanjing
2. Dept of Pharmacology, School of Basic Medical Sciences, Anhui Medical University
Publication Type:Journal Article
Keywords: autophagy; corilagin; high fat and high sugar diet; non-alcoholic fatty liver disease; p-AMPK
From: Chinese Pharmacological Bulletin 2023;39(9):1725-1730
CountryChina
Language:Chinese
Abstract: Aim To explore the effects of corilagin on non-alcoholic fatty liver disease induced by high-fat and high-sugar diet in mice via regulating AMPK-autophagy signaling. Methods Healthy 8-week-old male C57BL/6J mice were randomly divided into control group, model group and corilagin group. The mice of model group and corilagin group were fed with a high-fat and high-sugar diet for four weeks at the age of eight weeks. The corilagin group mice were also intraperitoneally injected with corilagin (20 mg • k g