Role and mechanism of DAPT in chronic social defeat stress-induced depressive-like behavior in mice

Author: Jing HUANG ¹ ; Yong LI ¹ ; Xin HE ¹ ; Wen-Xin DUAN ¹ ; Wen-Ning WU ¹
Author Information

1. Dept of Pharmacology, School of Basic Medical Sciences, Anhui Medical University
Publication Type:Journal Article
Keywords: autophagy; CSDS; DAPT; depression; inflammation; NLRP3 inflammasome
From: Chinese Pharmacological Bulletin 2023;39(10):1921-1928
CountryChina
Language:Chinese
Abstract: Aim To investigate the role and mechanism of DAPT in chronic stress-induced depressive-like behavior in mice. Methods C57BL/6J mice were treated with the chronic social defeat stress (CSDS) for 10 days to establish a depression model. Mice in the drug-treated group were injected intraperitoneally with 5 mg • kg