Effect of baicalin modulation of TLR4/MAPK/NF-ΚB signaling pathway on renal fibrosis in rats with diabetic nephropathy

Author: Xu-Dong ZHANG ¹ ; Gui-Ling REN ¹ ; Hui-Hui CHEN ¹ ; Jie ZHU ¹ ; Yun CHEN ²
Author Information

1. Dept of Pharmacy, The 901st Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army
2. School of Pharmacy, Anhui Medical University
Publication Type:Journal Article
Keywords: diabetic nephropathy; renal fibrosis; scutellarin; TLR4/MAPK/NF-ΚB
From: Chinese Pharmacological Bulletin 2023;39(10):1840-1846
CountryChina
Language:Chinese
Abstract: Aim To investigate the protective effect of baicalin on renal fibrosis in rats with diabetic nephrop- III (Col- III) athy (DN) and to investigate its mechanism of action. Methods A rat model of diabetic nephropathy was constructed. The rats were randomly divided into control group, model group, baicalin low dose group, baicalin medium dose group, baicalin high dose group and metformin group, with 10 rats in each group. Except for the control group, all rats in each group were fed with streptozotocin 65 mg • kg -