Ideas and methods of in vitro model establishment for cell microenvironment in COPD

Yan-Qin QIN; Han LIU; Jian-Sheng LI; Yan-Qin QIN; Han LIU; Jian-Sheng LI

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Ideas and methods of in vitro model establishment for cell microenvironment in COPD

Author: Yan-Qin QIN ¹ ; Han LIU ¹ ; Jian-Sheng LI ¹ ; Yan-Qin QIN ² ; Han LIU ² ; Jian-Sheng LI ³
Author Information

1. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases, Henan & Education Ministry of P.R. China
2. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine
3. The First Affiliated Hospital of Henan University of Chinese Medicine
Publication Type:Journal Article
Keywords: air-liquid interface culture; alveolar-capillary barrier; cell co-culture; cell microenvironment; COPD; in vitro model; lung organoids
From: Chinese Pharmacological Bulletin 2024;40(1):6-12
CountryChina
Language:Chinese
Abstract: Chronic obstructive pulmonary disease ( COPD ) major chronic disease threatening public health with complex pathological mechanisms. The change of the cell microenvironment of the lung is an important part of the pathophysiology of COPD. Cell culture technology is an important method to investigate the pathological mechanism of COPD and evaluate the pharmacological effect of medicine. Here we introduce the composition of the cell microenvironment of the lung, the change of the cell microenvironment in the pathological process of COPD, and summarize the application of in vitro model mimics cell microenvironment of COPD in the study of mechanism. In addition, we aim to put forward the ideas of the in vitro model establishment of cell microenvironment of COPD.