Progress of researches on the antiparasitic activity of antimicrobial peptide LL-37
10.16250/j.32.1374.2023157
- VernacularTitle:抗菌肽LL-37抗寄生虫活性研究进展
- Author:
Junchao LOU
1
;
Xiaoqin HE
1
Author Information
1. School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; National Health Commission Key Laboratory of Parasitic Disease Prevention and Control Technology, Jiangsu Provincial Key Laboratory of Parasites and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi, Jiangsu 214064, China
- Publication Type:Journal Article
- Keywords:
Parasite;
Human antimicrobial peptide;
LL-37;
Mechanism of action
- From:
Chinese Journal of Schistosomiasis Control
2024;36(1):98-104
- CountryChina
- Language:Chinese
-
Abstract:
Parasitic diseases caused by protozoan and helminth infections are still widespread across the world, notably in tropical and subtropical areas, which threaten the children and adult health. Long-term use of anti-parasitic drugs may result in reduced drug susceptibility and even drug resistance. Antimicrobial peptides have been demonstrated to inhibit parasite growth and development, which has potential antiparasitic values. LL-37, the only human antimicrobial peptide in the cathelicidin family, has been widely investigated. This paper reviews the progress of researches on the antiparasitic activity of LL-37, and discusses the prospects of LL-37 in the research of parasites.
