Case analysis of a patient with isavuconazonium-caused pancytopenia
- VernacularTitle:1例艾沙康唑致患者全血细胞减少的病例分析
- Author:
Xiaoping LIU
1
;
Xiaolu LIN
1
;
Jianfang LI
2
Author Information
1. Dept. of Pharmacy，Guangzhou Development District Hospital，Guangzhou 510730，China
2. Dept. of Pharmacy，Sun Yat-sen Memorial Hospital，Sun Yat-sen University，Guangzhou 510120，China
- Publication Type:Journal Article
- Keywords:
isavuconazonium;
pancytopenia;
case analysis;
adverse drug reaction
- From:
China Pharmacy
2024;35(7):881-885
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To correctly identify and deal with the adverse drug reaction as pancytopenia caused by isavuconazonium and to provide reference for the safe use of isavuconazonium. METHODS Clinical pharmacists analyzed a case of severe infection and renal insufficiency who experienced pancytopenia after using isavuconazonium. Clinical pharmacists screened the drugs used during hospitalization and evaluated the relationship between this adverse drug reaction and isavuconazonium， as well as the possible mechanisms， based on the half-life of the drugs and relevant literature. RESULTS & CONCLUSIONS The relationship between pancytopenia and isavuconazonium was assessed as “possibly related”. When using isavuconazonium， attention should be paid to avoiding the combination of drugs with the same mechanism or potential interaction. For patients who have a course of treatment for more than 2 weeks， have hematological abnormalities or complicated with liver and renal insufficiency， or should use it combined with other drug with same mechanism， it may be considered to increase the frequency of blood routine monitoring.
