Role of Wnt signaling Pathway in Diabetic Osteoporosis and Traditional Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20240402
- VernacularTitle:Wnt信号通路在糖尿病骨质疏松中的作用及中药干预的研究进展
- Author:
Yaqi ZHANG
1
;
Weiguo WANG
1
;
Qidong ZHANG
1
;
Huizhong BAI
2
;
Lingling QIN
3
;
Feng GAO
2
Author Information
1. China-Japan Friendship Hospital，Beijing 100029，China
2. Dongzhimen Hospital Beijing University of Chinese Medicine，Beijing 100700，China
3. Department of Science and Technology，Beijing University of Chinese Medicine，Beijing 100029，China
- Publication Type:Journal Article
- Keywords:
diabetic osteoporosis;
Wnt signaling pathway;
traditional Chinese medicine;
mechanism;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(9):283-292
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic osteoporosis （DOP） is a kind of bone complication caused by diabetes， which is characterized by the decrease of bone mineral density， the change of bone microstructure and the increase of bone fragility. The process of DOP is closely related to high glucose， insulin resistance， oxidative stress and other mechanisms. The Wnt/β-catenin signaling pathway plays an important role in mediating insulin resistance and bone metabolic balance in diabetes. Regulation of Wnt signal transduction promotes the expression of glycogen synthase kinase-3β（GSK-3β）phosphorylation and improves glucose and lipid metabolism. The Wnt/β-catenin signaling pathway is also an important way regulating osteocyte-driven bone remodeling， which not only plays an important regulatory role in the balance between osteoblasts and osteoclasts and improve bone metabolic homeostasis， but also promotes the expression of osteopontin， osteocalcin and type Ⅰ collagen， and improves bone proliferation and osteogenic differentiation by regulating the Wnt pathway. In recent years， the research of traditional Chinese medicine （TCM） in the prevention and treatment of DOP has gradually increased， and the exploration of TCM to interfere with the Wnt pathway to improve DOP has made some progress. This paper collects and summarizes the studies on the Wnt signaling pathway in glucose metabolism， bone metabolism and DOP worldwide in the past decade， as well as the related literature on the intervention of DOP by TCM compounds （classical and other compounds）， single Chinese medicine and TCM monomers based on the Wnt pathway， in order to provide a reference and direction for the development of new drugs for clinical prevention and treatment of DOP.
